Profenofos insecticide bioactivation in relation to antidote ... | 農藥合法資訊網
由AHGlickman著作·1984·被引用44次—Poisoningsignsinchicksadministeredtheorganophosphorusinsecticideprofenofoscorrelatedwithinvivoinhibitionofbrainacetylcholinesterase(AChE) ...
Poisoning signs in chicks administered the organophosphorus insecticide profenofos correlated with in vivo inhibition of brain acetylcholinesterase (AChE) activity. Mixtures of atropine with eserine, pyridinium oximes, or the bispyridinium compound SAD-128 increased the LD50 of coadministered profenofos by up to sevenfold in chicks and fourfold in mice. Atropine and the oximes were less effective as profenofos antidotes, indicating that profenofos-inhibited AChE may undergo rapid aging. Brain AChE from chicks poisoned with profenofos was not reactivated by pralidoxime methanesulfonate, although it was from chicks poisoned with the phosphoramidothiolate, methamidophos. Similarly, eel AChE, inhibited in vitro by bioactivated (-)-profenofos, the most toxic isomer, did not reactivate in contrast to that inhibited by methamidophos, nonbioactivated (-)-profenofos, and (+)-profenofos, with or without bioactivation. It appe...
Profenofos | 農藥合法資訊網
Profenofos | 農藥合法資訊網
Pesticides | 農藥合法資訊網
Profenofos | 農藥合法資訊網
Profenofos insecticide bioactivation in relation to antidote ... | 農藥合法資訊網
Profenofos, an Acetylcholinesterase | 農藥合法資訊網
佈飛松(Profenofos) 農藥有效成分檢驗方法一、農藥結構及物理 ... | 農藥合法資訊網
Poisoning with the S | 農藥合法資訊網
PROFENOFOS | 農藥合法資訊網
Profenofos PESTANAL®, analytical standard | 41198 | 農藥合法資訊網
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