Application and prospects of butylphthalide for the treatmen ... | 農藥合法資訊網

由XQChen著作·2019·被引用13次—The3-N-butylphthalide(NBP)comprisesoneofthechemicalconstituentsofceleryoil.Ithasaseriesofpharmacologicmechanismsincluding ...

3-N-butylphthalide (NBP) comprises a family of optical isomers that includes l-3-N-butylphthalide (l-NBP), d-3-N-butylphthalide (d-NBP), and dl-3-N-butylphthalide (dl-NBP).[1] L-NBP is one of the chemical constituents in celery oil, whereas dl-NBP is synthetic and an important neuroprotective drug for the treatment of neurologic diseases. Its chemical formula is C12H14O2 and molar mass is 190.24 g/mol. Dl-NBP is a fat-soluble substance that can freely pass across the blood-brain barrier. Further, it is absorbed rapidly, with a peak blood concentration seen at 1.25 h. Moreover, it has a long-lasting pharmacologic effect, as the elimination half-life of dl-NBP is 11.84 h. Its main target organs are brain and adipose tissue, and dl-NBP undergoes extensive metabolism in the human body; the major metabolites of this compound in human plasma were found to be 3-OH-NBP, 10-OH-...