Paraquat poisoning | 農藥合法資訊網
由KRaghu著作·2013·被引用34次—Paraquat(1,r-dimethyl-4,4'-bipyridiumdichloride),abrownsyrupyliquidisaneffectiveherbicidethathaslowchronictoxicitybecauseofitsrapiddeactivation ...
DISCUSSIONWhen consumed orally, Paraquat is sequestered in the lungs and causes a release of hydrogen and superoxide anions which cause lipid damage in the cell membranes, causing oxidant free radical damage that results in hepato/nephrotoxicity and pulmonary fibrosis.[14,15,16,17,18] In fatal cases of paraquat poisoning, histopathological findings range from pulmonary congestion, edema, and hemorrhage to extensive pulmonary fibrosis.[19] Paraquat toxicity produces local as well as systemic effects.[12,20] As seen in the present case, paraquat ingestion results in an inflammation of the tongue, oral mucosa and throat, corrosive injury to the gastrointestinal tract, renal tubular necrosis, hepatic necrosis, and pulmonary fibrosis.[14] The patient complains of burning and ulceration of the throat, tongue, and esophagus.[8,14,20,21] The pulmonary manifestations of paraquat poisoning begin...
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